Enhance Biotherapeutics Design and Development

Biotherapeutics offer a range of unique benefits over small molecule drugs. Their increased affinity and selectivity have allowed researchers to address new and difficult targets. This has led to a dramatic increase in R&D projects centered on antibodies and other biological modalities for treatment such as bispecifics. However, these projects must also overcome similar challenges in safety and pharmacokinetics faced by small molecules, albeit from a different perspective. Factors such as high immunogenicity or low solubility can kill development on an otherwise effective candidate.

Modeling and simulation can significantly advance the development of these new classes of therapeutics. For example, researchers can predict an antibody’s formulation properties and suggest mutations to improve them rapidly and at low cost compared to laboratory experimentation alone. BIOVIA Discovery Studio offers a rich set of tools to help guide the design of biotherapeutics, allowing teams to optimize the performance of candidates in silico and streamlining their physical work.


  • Automated modeling cascade to easily and rapidly generate high quality 3D antibody full-length, Fab or Fv models from a set of light and heavy antibody chain sequences and a curated PDB antibody template database
  • Full support for commonly used antibody annotation schemes -  IMGT, Chothia, Kabat and Honegger
  • Simultaneously and independently perform multiple sequence alignments of heavy and light chains
  • Additional expert tools to identify antibody template structures and build high quality homology models
  • Ability to build bispecific full length antibody structures
  • Refine CDR loops using either template, loop grafting or de novo loop modeling
  • Perform detailed model analysis

Start Your Journey

Accelerate your drug discovery with BIOVIA Discovery Studio. 

Join the conversation in the BIOVIA Drug Discovery & Development Community!

Also Discover

Ligand- and Pharmacophore-based Design
De Novo Drug Design, Multi-Target Drug Design and Activity Profiling
Macromolecule Design and Analysis
Comprehensive Portfolio of Validated Scientific Tools for Every Aspect of Macromolecule-based Research
Protocols for State-of-the-art Molecular Dynamics Simulations 
Structure-based Design
Comprehensive, Scalable Portfolio of Scientific Tools to Support Structure-based and Fragment-based Design
QSAR, ADMET & Predictive Toxicology
Tools for Designing Therapeutics with Favorable Pharmacokinetic Properties and Safety Profiles 
Free, Feature-Rich Molecular Visualizer
BIOVIA Discovery Studio
Comprehensive Modeling and Simulation for Life Sciences Research
Accelerate Innovation in Life Sciences Research and Development

Learn What BIOVIA Can Do for You

Speak with a BIOVIA expert to learn how our solutions enable seamless collaboration and sustainable innovation at organizations of every size.

Get Started

Courses and classes are available for students, academia, professionals and companies. Find the right BIOVIA training for you. 

Get Help

Find information on software & hardware certification, software downloads, user documentation, support contact and services offering