BIOVIA DATABASES

ENRICHING R&D

 

BIOVIA supports information-driven R&D by delivering unique answers to molecular property, chemical sourcing, bioactivity, and toxicology questions in the context of laboratory workflows—saving time, reducing costs, and enhancing decision confidence.
BIOVIA Databases are available in various formats that can be accessed via in-house installation or hosted service.

 

Deeply Integrated with the BIOVIA Portfolio

BIOVIA content is accessible out-of-the-box through:

Content to Support your R&D

    Bioactivity

    BIOVIA provides insight into druggability and intelligence on investigational drugs by providing access to one of the world’s leading collections of bioactivity data.

    MDDR

    Understand the competitive space for biologically active molecules and develop structure-activity relationships (SARs) using one of the most authoritative and current collections of bioactivity findings for newly launched or developmental drugs. MDDR is an electronic version of the Drug Data Report publication and is jointly produced by BIOVIA and Clarivate Analytics (España) SAU.

    Following criteria is a guide for MDDR products selection:

    • New products in drug substance patents with biological results, preferably from companies or relevant drug discovery universities and research centers.
    • New products in journal articles or conference abstracts, preferably with good preclinical data or, alternatively, other novelty such as:
      • New chemical scaffold for specific biological activity
      • New mechanism or mechanism with very few data available in the literature.
      • New therapeutic strategy.
      • New therapeutic indication.
      • New code, from a company

    First time Launched products are included as well.

    Terms for mechanism of action indexation, when related with genes and protein targets, are based on UniProt® nomenclature.

    Toxicity

    Anticipate adverse effects based upon chemical structure and link structure with metabolism information in the largest structure-searchable compendium of compounds with reported in vivo and in vitro toxic properties. Toxicity database includes Registry of Toxic Effects of Chemical Substances (RTECS®) database that is updated quarterly. Six categories of data types are covered:

    • Acute Toxicity
    • Mutagenicity
    • Skin/Eye Irritation
    • Tumorigenicity
    • Reproductive Effects
    • Other Multiple Doses

    In addition, the following data sources (no further updates) are included in the Toxicity database.

    • Chemical Carcinogenesis Research Information System (CCRIS), produced by the National Cancer Institute (NCI) ; Ref. 1938-2006
    • Genetic Toxicity (GENE-TOX), produced by the U.S. Environmental Protection Agency (EPA) ; Ref. 1952-1987
    • Genotoxicity, produced by genetic toxicity testing program of the US National Toxicology Program (NTP) ; Ref. 1983-1996
    • Additional Carcinogenicity, Hepatotoxicity abstracted from scientific literature by MDL (now Dassault Systèmes BIOVIA) :
      • BIOVIA Carcinogenicity; Ref. 2000
      • BIOVIA Hepatotoxicity; Ref. 1999

     

    RTECS

    Registry of Toxic Effects of Chemical Substances (RTECS®) was built and maintained by the National Institute of Occupational Safety and Health (NIOSH) from 1971 through January 2001. Dassault Systèmes BIOVIA continues the production of the RTECS file using the same data selection criteria and rules established by NIOSH. BIOVIA distributes quarterly updates to licensees of the RTECS database under the terms of the License and Distribution Agreement entered into on October 29, 2001 between MDL (now Dassault Systèmes BIOVIA) and the United States Public Health Service within the Department of Health and Human Services. RTECS is a comprehensive collection of basic toxicity information for over 190,000 chemical substances from pharmaceuticals to foodstuffs.

     

    Sourcing

    These structure-searchable databases provide supplier compound information including supplier, location, package, purity, and cost information helping you to make informed compound purchasing decisions and cut costs.

    Available Chemicals Directory (ACD)

    BIOVIA ACD is the Gold Standard for chemical sourcing in pharmaceutical, biotechnology, chemical, and agrochemical companies worldwide—used and trusted for more than 25 years by over 20,000 scientists at over 500 sites.

    ACD consolidates chemical supplier catalogs into an easy-to-access, structure-searchable database providing information on:

    • Product purities
    • Available quantities
    • Prices with supplier ordering information
    • Forms
    • Grades
    • GHS classification for products
    • SDS links to supplier product pages 

    BIOVIA ACD is one of the largest structure-searchable collections of commercially available chemicals in the world, with pricing and supplier information for:

    • Over 10 million unique chemicals, including 3D models
    • Over 25 million products
    • Over 70 million packages
    • From about 940 suppliers

    With BIOVIA ACD you can:

    • Identify and locate commercial sources
    • Make side-by-side comparisons of purity, quantity and price
    • Save valuable time by accessing information from a single source
    • Identify the optimal set of compounds for a synthesis or library, with confidence that those compounds will be available at the indicated prices from the selected suppliers
    • Quickly, easily and confidently order compounds from multiple suppliers using the eMolecules fulfillment service

    Using powerful chemical search functionality it is easy to find suppliers providing analogs of interest. The database also includes 3D models and links to ChemADVISOR EH&S health and safety data.

    Screening Compounds Directory (SCD)

    BIOVIA SCD complements BIOVIA ACD by consolidating HTS supplier offerings into an easy-to-access, structure-searchable database of over 9 million compounds within commercially available sample collections.