A large number of experimental in-vitro pre-clinical testing devices have been used in the evaluation of new implant designs for total knee replacement, but it is time-consuming and cost prohibitive to evaluate hundreds of design variations during design phase. In-silico knee simulator has provided an efficient way to perform component design evaluations under a variety of dynamic loadings, while it remains a challenge to evaluate the predictive accuracy due to the lack of in-vivo verification. The commercial software Abaqus, Isight and a specialized tool Abaqus Knee Simulator have been widely used to predict implanted knee mechanics. In the paper, a systematical in-vivo experimental evaluation has been carried out in Abaqus Knee Simulator with calibrated soft-tissue properties for gait cycle.
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