Be the next big change > Dassault Systèmes

Be the Next Game Changer

Post Doc - BIOVIA Biologics Drug Design- Fall 2022

United States, CA, San Diego
Internship
6/6/2022
527010

Imagine New Horizons…

As an intern within the Biologics Development Team within Dassault Systemes BIOVIA, you will help develop and validate scientific protein modeling and design methods for our life sciences customers. 

Shape your career with 3DS! #WeAre3DS 

This is a paid internship available with a flexible fall start date and duration.  You will be working in the Dassault Systèmes BIOVIA office at 5005 Wateridge Vista Drive, San Diego, CA 92121

What your role will be?

You will have access to our advanced modeling and machine learning algorithms and state of the art visualization, and use the BIOVIA Discovery Studio suite with Pipeline Pilot for the research.

As a Biologics Development Group post-doc, you will develop models to study protein design problems, such as antibody-antigen binding interfaces. 

This work will expose you to the widely adopted scientific development platform, Pipeline Pilot, and the innovative research topics in biologics therapeutic design.

A peer-reviewed publication is desirable based on the outcome of the research.

The Challenges ahead

Develop a new algorithm for protein modeling and design.  Area of interests include, but are not limited to the following:

  • Scoring function and ML model to rank protein – protein docking poses
  • None-linear B-cell Epitope mapping
  • Antibody paratope mapping and clustering
  • Protein post-translational modification

 

Your Key Success Factors

Ph.D.  in computational biology or related field 

Working experience with in silico antibody design

Working experience with protein-protein docking algorithms and scoring functions

Experience in object oriented programing using either C++, Java, or Python

Working experience in BIOVIA Pipeline Pilot is desirable

Experience in developing protein 3D and 3D-shape descriptors is desirable

Experience in applying machine learning algorithms to solve biological problems is desirable

Ability to work in a collaborative team, attention to detail, scientific curiosity, strong communication skills, and a desire to develop high quality software.

Equal opportunity

In order to provide equal employment and advancement opportunities to all individuals, employment decisions at 3DS are based on merit, qualifications and abilities. 3DS is committed to a policy of non-discrimination and equal opportunity for all employees and qualified applicants without regard to race, color, religion, gender, sex (including pregnancy, childbirth or medical or common conditions related to pregnancy or childbirth), sexual orientation, gender identity, gender expression, marital status, familial status, national origin, ancestry, age (40 and above), disability, veteran status, military service, application for military service, genetic information, receipt of free medical care, or any other characteristic protected under applicable law. 3DS will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Covid statement

Our Company requires all U.S. employees to be fully vaccinated against COVID-19 and to provide documentation of full vaccination, unless qualified for a medical, religious or state-required accommodation or otherwise exempt consistent with applicable law.  Although accommodation requests will be considered (and granted where appropriate/possible), it may be determined that a candidate is unable to adequately perform the essential functions of the position without imposing an undue hardship due to customer requirements, staffing needs, or other business reasons. Definition of full-vaccination: Employees are considered to be fully vaccinated two weeks after their second dose in a 2-dose series or two weeks after a single-dose vaccine.
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BIOVIA provides scientific solutions to discover, design, develop and deliver innovative drugs, materials and formulas.