DIR-4254

Take into account relative stereo groups (enhanced stereo) in the perception of meso symmetry. Molecules that would have been classified as meso are no longer perceived as meso if they have enhanced stereo.

This change has implications for Exact and Flexmatch searches that take into account stereo, as molecules with enhanced stereo that were perceived as meso before are now considered chiral and might not match similar molecules with different stereo.

DIR-4251

A problem perceiving aromaticity of six-member rings containing atoms such as sulfur or phosphorus with alternating single and double bonds has been corrected. In previous releases, the perceived aromaticity could depend on the positioning of the double bonds. Now, the aromaticity is perceived identically, regardless of the double bond positions. A previous fix in the 2019 release resolved the issue only partially.

DIR-4260

Fixed an issue with the License Check on the Linux platform that prevented the installation of BIOVIA Direct 2022 SP1 HF1.