T58-2025 - Notification Regarding the Release of BIOVIA Direct 2026
We are providing this Technical Note to inform you about the release of BIOVIA Direct 2026. It includes the following enhancements and fixed defects.
Program
BIOVIA Direct
Operating System
All supported operating systems
Description
We are providing this Technical Note to inform you about the release of BIOVIA Direct 2026. It includes the following enhancements and fixed defects.
Enhancements
This release of BIOVIA Direct includes the following enhancements.
| User Story | Description |
|---|---|
| DIR-4272 | The creation of SMILES from structures with enhanced stereo chemistry in BIOVIA Direct is now consistent with BIOVIA Draw and the Pipeline Pilot Chemistry collection. |
| DIR-4407 | The molimage() and rxnimage() operators and their respective functions mdlaux.molimag() and mdlaux.rxnimage() provide the new option 'ShowSequenceView'. When set to true, biological sequences in the molecule or reaction are rendered in the Sequence View. |
| DIR-4508 | Long names have been added to HELM monomers to be consistent with original Pistoia library. |
| DIR-4512 | The new Direct operator logp() and function mdlaux.logp() calculate the log P value of a molecule. |
| DIR-4513 | The new Direct operator hbonddonors() and function mdlaux.hbonddonors() calculate the number of hydrogen donor atoms of a molecule. |
| DIR-4514 | The new Direct operator hbondacceptors() and function mdlaux.hbondacceptors() calculate the number of hydrogen acceptor atoms of a molecule. |
| DIR-4515 | The new Direct operator numlipinskiviolations() and function mdlaux.numlipinskiviolations() calculate the number of Rule of Five violations of a molecule. |
| DIR-4516 | The new Direct operator logd() and function mdlaux.logd() calculate the log D value of a molecule at a given pH value. |
| DIR-4517 | The new Direct operator logs() and function mdlaux.logs() calculate the water solubility value log S of a molecule. The operator and function provide the options to calculate the value based on the 'estate' or the 'qikprop' model. |
| DIR-4518 | The new Direct operator pka() and function mdlaux.pka() calculate the pKa value of a molecule. pKa values can be calculated for the acidic and basic sites of a molecule. |
| DIR-4519 | The new Direct operator tpsa() and function mdlaux.tpsa() calculate the Topological Polar Surface Area value of a molecule. |
| DIR-4520 | The new Direct operator fsp3() and function mdlaux.fsp3() calculate the Drug Likeness (Fsp3) value of a molecule. |
| DIR-4521 | The new Direct operator heavyatomcount() and function mdlaux.heavyatomcount() calculate the number of heavy (non-hydrogen) atoms of a molecule. |
| DIR-4522 | The new Direct operator rotatablebonds() and function mdlaux.rotatablebonds() calculate the number of rotatable bonds of a molecule. |
Fixed Defects
This release of BIOVIA Direct includes the following fixed defects.
| Defect | Description |
|---|---|
| DIR-4490 | The enhanced axial stereochemistry of allene structures is now considered in flexmatch searches. |
| DIR-4492 | The enhanced axial stereochemistry of allene structures is now considered in substructure searches. Please also see the release note on DIR-4559. |
| DIR-4489 | The enhanced axial stereochemistry of allene structures is now considered in flexmatch searches. |
| DIR-4475 | The Direct documentation no longer contains references to the removed 'lib' directory. |
| DIR-4503 | The DCSAMPLES.DMP dump file no longer includes index data of specific Direct versions. |
Resolution
BIOVIA Direct 2026 was released on 28-NOV-2025 and is available for download at https://software.3ds.com under BIOVIA products and can be found under:
Product line: Lab, Scientific and Content Solutions
Release: BIOVIA 2026
Level: BIOVIA 2026 Golden
Fixes for this level: N/A
How to contact BIOVIA Support
If you have any questions, please contact BIOVIA Support.
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