T04-2026 - Notification Regarding the Release of BIOVIA Direct 2026 HF1
We are providing this Technical Note to inform you about the release of BIOVIA Direct 2026 HF1. It includes the following enhancements and fixed defects.
Program
BIOVIA Direct
Operating System
All supported operating systems
Description
We are providing this Technical Note to inform you about the release of BIOVIA Direct 2026 HF1. It includes the following enhancements and fixed defects.
Enhancements
This release of BIOVIA Direct includes the following enhancements.
| User Story | Description |
|---|---|
| DIR-4565 | The documentation of the ENHANCEDSTEREOSMI flag was updated. This follows the alignment of the standard behavior when reading and writing SMILES in BIOVIA Pipeline Pilot Chemistry, BIOVIA Direct, and BIOVIA Draw (DIR-4272). |
| DIR-4523 | The Direct Reference Guide now includes descriptions for the following life science calculators that were added to BIOVIA Direct 2026: fsp3, mdlaux.fsp3 hbondacceptors, mdlaux.hbondacceptors hbonddonors, mdlaux.hbonddonors heavyatomcount, mdlaux.heavyatomcount logd, mdlaux.logd logp, mdlaux.logp logs, mdlaux.logs numlipinskiviolations, mdlaux.numlipinskiviolations pka, mdlaux.pka rotatablebonds, mdlaux.rotatablebonds tpsa, mdlaux.tpsa |
| DIR-4510 | The new option 'ShowSequenceView' for the molimage() and rxnimage() operators and functions is now documented. |
Fixed Defects
This release of BIOVIA Direct includes the following fixed defects.
| Defect | Description |
|---|---|
| DIR-4559 | Substructure searches of molecules with enhanced axial stereochemistry now find all matches irrespective of the input format of the query. |
Resolution
BIOVIA Direct 2026 HF1 was released on 21-JAN-2026 and is available for download at https://software.3ds.com under BIOVIA products and can be found under:
Product line: Lab, Scientific and Content Solutions
Release: BIOVIA 2026
Level: BIOVIA 2026 Golden
Fixes for this level: BIOVIA 2026 Golden HF1
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If you have any questions, please contact BIOVIA Support.
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