Technical Note T36-2025: BIOVIA Pipeline Pilot Chemistry SDK 2025 SP1
Announcing the the release of BIOVIA Pipeline Pilot Chemistry SDK 2025 SP1
Program
BIOVIA Pipeline Pilot Chemistry SDK
Operating System
All supported operating systems
Description
We are providing this Technical Note to inform you about the release of BIOVIA Pipeline Pilot Chemistry SDK 2025 SP1 which includes the following enhancements and fixed defects:
Enhancements
This release of BIOVIA Pipeline Pilot Chemistry SDK includes the following enhancements.
| Description | Areas Affected | Risk Level | Jira Issue ID |
| Improved the 2D layout of molecules with Markush bonds and Haptic bonds. | PCHE: Chemistry Depiction, PCHE: Pipette | Low | PCHE-6862 |
| Added a new component, HELM to PNG, as a prototype to allow server-side generation of Pipette Biosketcher monomer view images. | PCHE: Biologics, PCHE: Chemistry Depiction | Low | PCHE-7896 |
| Added support for "No Structure" (empty molecules). | PCHE: Pipette | Low | PCHE-8407 |
| Added support for data sgroups for atoms, bonds, and repeat units. | PCHE: Pipette | Low | PCHE-8408 |
| Pipette Monomer Review now allows you to create Ribose derivatives with R4 groups. | PCHE: Pipette | Low | PCHE-8416 |
| You can now specify axial stereochemistry. | PCHE: Chemical Perception | Low | PCHE-8417 |
| Sketching and positioning of salt fragments is improved in molecules and reactions. | PCHE: Pipette | Low | PCHE-8501 |
| You can now enter a sequence in the form of a string with residue letters. | PCHE: Biologics, PCHE: Pipette | Low | PCHE-8520 |
| Improved salt depiction by stacking vertically to optimize use of space. | PCHE: Pipette | Low | PCHE-8542 |
| Improved Pipette Biosketcher sequence view to show reaction components horizontally instead of vertically. | PCHE: Biologics | Low | PCHE-8543 |
| Added support for pasting reaction RXN files with sequences represented by Full CTAB expanded residues. | PCHE: Pipette | Low | PCHE-8545 |
| Added full ctab molfile support to the Pipette Biosketcher when using SCSR monomers. | PCHE: Pipette | Low | PCHE-8546 |
Additional features and fixes:
| PCHE: Pipette | Low | PCHE-8719 |
Fixed Defects
This release of BIOVIA Pipeline Pilot Chemistry SDK includes the following fixed defects.
| Severity | Description | Areas Affected | Risk | Defect |
| Major | Improved depiction of a linker between two peptides in some circumstances. | PCHE: Pipette | 1 (Low) | PCHE-8656 |
| Major | Fixed an issue where haptic bonds in reactions did not work correctly. | PCHE: Chemical Perception, PCHE: Chemistry Depiction, PCHE: PPChemAPI | 1 (Low) | PCHE-8716 |
| Minor | Fixed the depiction of Markush bonds in brackets, and variable repeat units. The round brackets are converted to square brackets. | PCHE: Chemistry Depiction | 1 (Low) | PCHE-6148 |
| Minor | Improved rendering and layout of molecules and reactions with haptic systems. | PCHE: Chemical Perception, PCHE: Chemistry Depiction, PCHE: PPChemAPI | 1 (Low) | PCHE-7778 |
| Minor | Pipette Sketcher no longer allows adding enhanced stereochemistry labels to a tetrahedral stereo center that is (only) marked with a single either bond. | PCHE: Pipette | 1 (Low) | PCHE-8587 |
Resolution
BIOVIA Pipeline Pilot Chemistry SDK 2025 SP1 was released in June 2025 and is available for download at https://software.3ds.com under BIOVIA products:
Product line: Lab, Scientific and Content Solutions
Release: BIOVIA 2025
Level: BIOVIA 2025 Refresh 2
Fixes for this level: -
How to contact BIOVIA Support
If you have any questions, please contact BIOVIA Support.
Need Assistance?
Our support team is here to help you make the most of our software. Whether you have a question, encounter an issue, or need guidance, we've got your back.