T62-2025 Discovery Studio 2026
Release of BIOVIA Discovery Studio 2026
DEC | 1st, 2025
Program
BIOVIA Discovery Studio
Operating System
All supported operating systems
Description
We are providing this Technical Note to inform you about the release of BIOVIA Discovery Studio 2026 which includes the following enhancements and fixed defects:
Enhancements
This release of BIOVIA Discovery Studio includes the following enhancements.
| User Story | Description |
|---|---|
| DSC-33708 | The RCSB Structure Search protocol can now filter hits by organism and sequence similarity. |
| DSC-37775 | The Measure Trajectory Features protocol includes a new feature "Pocket Detection", which allows for detection and measurement of pocket volumes on the basis of occurrence and spatial analysis. |
| DSC-38064 | A new protocol, Export Conformations as Trajectory, exports conformations from a molecule window to a trajectory file in DCD format. |
| DSC-38452 | A new protocol, Detect and Analyze Pockets, assesses changes in pocket characteristics by analyzing and identifying transient and static pockets within the protein structure across an input trajectory. |
| DSC-38484 | The Jobs Explorer data (in the Jobs.xml file) is now backed up when starting and exiting the Discovery Studio client. |
| DSC-38520 | The Measure Trajectory Features protocol is improved to handle edge cases. |
| DSC-38868 | Discovery Studio requires an installation of Pipeline Pilot 2026. |
| DSC-38956 | Entity numbers are now read from mmCIF files for protein and nucleic acid chains, and are displayed in the AminoAcidChain or NucleicAcidChain tab of the Molecular Data Table. |
| DSC-38957 | The Discovery Studio BLAST Results Window can now load data from mmCIF files and can handle multi-character chain names. |
| DSC-38984 | A new script for exporting trajectory conformations as images, Save Trajectory as Images, is available from the Scripts > Export menu in the Discovery Studio client. |
| DSC-38998 | A new script for exporting macromolecules as mmCIF files, Save as mmCIF, is available from the Scripts > Export menu in the Discovery Studio client. |
| DSC-38999 | The Discovery Studio client default location for File > Open URL is changed from .pdb to .cif. |
| DSC-39100 | Tooltips in the Discovery Studio client Scripts menu now have help text links. |
| DSC-39177 | The SQLite library is updated to version 3.50.4. |
| DSC-39181 | The PDB, PDB_nr95, and Swiss-Prot BLAST databases are updated using data available as of April 2025. |
| DSC-39221 | The System Requirements document is updated to encourage users to install the client on a machine that uses an English language locale. |
| DSC-39308 | The Antibody Database is updated with data from 8083 antibody structures from the RCSB database as of April 2025. |
| DSC-39350 | The detail of the charmm.log file is reduced for the Calculate Mutation Energy (Binding) protocol to reduce the file size. |
| DSC-39400 | Perl is updated to version 5.40.2. For information, see https://www.perl.org/. |
| DSC-39407 | MODELER is updated to version 10.7. |
| DSC-39539 | CCDC GOLD version 2025.1 is now supported. |
| DSC-39564 | OpenSSL is updated to version 3.5.4. |
| DSC-39589 | Qt is upgraded to 5.15.19. |
| DSC-39685 | The data shown in the Discovery Studio Jobs Explorer can now be selected and copied to the clipboard. |
| DSC-39827 | A new protocol, Standard Dynamics Cascade (OpenMM), runs molecular dynamics with GPU acceleration using OpenMM. |
| DSC-39836 | A new protocol, Set up Relative FEP Calculations (OpenFE), prepares inputs for the Relative FEP Calculations (OpenFE) protocol using new atom mapping schemes and by designing a ligand perturbation network. |
| DSC-39852 | A new protocol, Analyze Trajectory Features, analyzes allosteric motions from trajectories using features of interest. |
| DSC-40105 | The Discovery Studio Linux client is removed from the release. |
| DSC-40206 | A new protocol, Relative FEP Calculations (OpenFE), runs relative binding free energy calculations using the OpenFE framework, which leverages the OpenFF forcefield and OpenMM. |
| DSC-38959 | The example utility protocol Update BLAST Databases is enhanced to process mmCIF files and to create version 5 databases. |
| DSC-39307 | The example utility protocol Update Antibody Databases is enhanced to process mmCIF files. |
| DSC-39814 | Python components are updated to maintain compatibility with Pipeline Pilot. |
| DSC-39431 | Protocols that use Modeler are no longer limited to the RCSB PDB file format. |
Fixed Defects
This release of BIOVIA Discovery Studio includes the following fixed defects.
| Defect | Description |
|---|---|
| DSC-38848 | The Calculate Mutation Energy (Stability) and Calculate Mutation Energy (Binding) protocols now warn you when the number of mutants specified in either the "Mutations" or "Mutations From Alignment" parameters exceeds what is specified in the "Maximum Number of Mutants" parameter. |
| DSC-38867 | The number of intermediate files for Calculate Mutation Energy (Stability) and Calculate Mutation Energy (Binding) protocols are reduced to prevent possible failure when running a large number of mutations. |
| DSC-38725 | The Enable Additional Features button in the lower-right corner of the Discovery Studio client now directs you to the License Administrator to configure licensing. |
| DSC-39429 | Guidance on calculating RMSD between a ZDOCK ligand pose and the ligand in an experimental complex is clarified. |
| DSC-39560 | Inverting a selection in the Discovery Studio client no longer causes Assembly and Group objects to become selected. When new Groups are created, the objects within any selected Assembly and Group objects are included. |
| DSC-39561 | The Measure Trajectory Features protocol no longer incorrectly incorporates solvent atoms into its calculations when the input system contained solvent ions other than sodium or chloride. |
| DSC-39710 | The license configuration script (config_lp_location) is added to the Discovery Studio server installation. |
| DSC-39744 | Parallel Discovery Studio components no longer fail when they are added in serial, and copying input files. |
| DSC-39991 | Protocols with the Input Ligands parameter no longer fail when selecting multiple files. |
| DSC-37536 | In the Screen Library protocol, the parameter help for Fitting Method was updated to include a description for NONE. |
| DSC-39348 | Gap information for some mmCIF files that had residues missing from the start of a chain is now correctly handled. |
| DSC-40002 | Failures in the BLAST Search (NCBI Server) protocol due to issues on the NCBI server, such as CPU limit being exceeded, now generate a more meaningful error message. |
| DSC-40187 | The Discovery Studio client EBI AlphaFold DB default site definition in the Open URL dialog now retrieves version v6. However, version v4 URL may still appear if preferences have been imported from an earlier release. You can update the version in the Edit > Preferences >Files Explorer > URL Location page. |
Resolution
BIOVIA Discovery Studio 2026 was released in November 2025 and is available for download at https://software.3ds.com under BIOVIA products:
Product line: Lab, Scientific and Content Solutions
Release: BIOVIA 2026
Level: BIOVIA 2026 Golden
Fixes for this level: -
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If you have any questions, please contact BIOVIA Support.
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