T56-2025 Pipeline Pilot 2026
Release of BIOVIA Pipeline Pilot 2026
NOV | 27th, 2025
Program
BIOVIA Pipeline Pilot
Operating System
All supported operating systems
Description
We are providing this Technical Note to inform you about the release of BIOVIA Pipeline Pilot 2026 which includes the following enhancements and fixed defects:
Enhancements
This release of BIOVIA Pipeline Pilot includes the following enhancements.
| Description | Areas Affected | Risk | Issue ID |
|---|---|---|---|
| The Pipeline Pilot Server installer now supports installing an SSL Certificate during installation and setting the Port Configuration mode ("SSL Only", "HTTP Only", or "SSL and HTTP"). For new installations, the default port configuration will now be "SSL Only" whereas Pipeline Pilot server upgrades and reinstallations will default to their existing port configuration settings and reusing the existing SSL certificate. | PPC: Installer | Low | PPC-5325 |
| Pipeline Pilot 2026 only supports the use of enhanced license files that include a longer checksum. These files can be identified by the inclusion a "v2" label within the file. Contact Customer Support if you require a new license file that uses the new format. | PPC: Installer | Medium | PPC-12015 |
| The expiration of the vendor-supplied default SSL certificate is updated. This is intended for bootstrapping the server. All installations should replace it with a valid, signed certificate for their individual environments | PPC: Server Infrastructure | Low | PPC-12004 |
| The Apache httpd server is updated to version 2.4.65. | PPC: Third Party Libraries | Medium | PPC-11976 |
| The SQLite library is now the latest version 3.50.4. | PPC: Third Party Libraries | Low | PPC-11876 |
| The libssh is updated to the latest available version 0.11.3. | PPC: Third Party Libraries | Low | PPC-12021 |
| The expat XML parser library is updated to the latest available version (2.7.3). | PPC: Third Party Libraries | Low | PPC-12042 |
| OpenSSL is updated to version 3.5.4. | PPC: Third Party Libraries | Low | PPC-12053 |
| The embedded Tomcat server is updated to version 9.0.107. | PPC: Third Party Libraries | Low | PPC-12037 |
| The Java SDK included with Pipeline Pilot is updated to version 17.0.16. | PPP: Third Party Libraries | Low | PPP-53771 |
| The older and unsupported 7.1 DataDirect ODBC drivers have been removed from the Pipeline Pilot 2026 release. In addition, the 8.x DataDirect ODBC drivers have been updated to the latest available version. Note that the Windows drivers require the Microsoft Visual C++ Redistributable version to be at least 14.40.33810. | PPP: Third Party Libraries | Low | PPP-54155 |
| Chromium Embedded is updated to the latest version as of August 2025. | PPP: Third Party Libraries PPP: Professional Client | Medium | PPP-53835 |
| scikit-optimize 0.10.2 is now available as part of the Python Essentials Libraries for use in the Python (on Server), Python Script, and Python Jupyter Notebook components. | PPP: Third Party Libraries PPP: Component SDKs | Low | PPP-53445 |
| Python is updated to version 3.12.11. The Python modules in the Essentials library are updated to the following versions: * numpy: 2.3.0 * pandas: 2.3.1 * bottleneck: 1.5.0 * scipy: 1.16.0 * matplotlib: 3.10.0 * scikit-learn: 1.7.0 * scikit-optimize: 0.10.2 | PPP: Third Party Libraries PPC: Component SDKs | Medium | PPC-11787 |
The Perl installation used for the Perl (on Server) component is updated to Perl 5.40.2. For more information, see https://www.perl.org/. For this update, there is a change in behavior in the included external LWP::UserAgent module with regards to disabling Https certificate verification, which may change the behavior of existing Perl (on server) components. The following is from https://metacpan.org/pod/LWP::UserAgent#ssl_opts: "Please note that recently the overall effect of this option with regards to SSL handling has changed. As of version 6.11 of LWP::Protocol::https, which is an external module, SSL certificate verification was harmonized to behave in sync with IO::Socket::SSL. With this change, setting the verify_hostname option no longer disables all SSL certificate verification, only the hostname checks. To disable all verification, use the SSL_verify_mode option in the ssl_opts attribute. For example: $ua->ssl_opts(SSL_verify_mode => IO::Socket::SSL::SSL_VERIFY_NONE);>" | PPP: Third Party Libraries, PPC: Component SDKs | Medium | PPC-11840 |
The Velocity library used by the HTML Template component is updated to 2.4.1. The change from the 1.x to 2.x Velocity library may require some small changes to template content entered into the HTML Template component. Check online resources for more information. For example, see https://velocity.apache.org/engine/2.0/upgrading.html#vtl-changes. However, there a new compatibility parameter on the component to provide backward compatibility for existing components. For such components, where this parameter does not exist, the component behavior is to support 1.x template content. | PPP: Third Party Libraries PPP: Reporting | Low | PPP-54075 |
| A new Security option, Block Execution of Restricted Protocols, prevents users from running inaccessible protocols directly using a URL. | PPP: Administration | Low | PPP-53775 |
| When running a protocol in Web Port, all results files are now listed on the results page. Text and HTML files (.txt and .htm/.html) are still opened in a separate tab. | PPP: Web Port | Low | PPP-52505 |
| There is now a clear message if a file could not be uploaded in Web Port because the file length exceeded the maximum. | PPP: Web Port | Low | PPP-52518 |
The Http Connector and File Reader components (when reading from URLs) now support detecting Byte Order Marks (BOMs) in response data. For information about BOMs, see https://en.wikipedia.org/wiki/Byte_order_mark. For the Http Connector, this detection is enabled as part of the "Detect Character Encodings" parameter. For the File Reader components (for example, Text Reader), the detection is enabled as part of the "UTF-8 Auto Detect" parameter. For components in existing protocols that have these settings already configured, this may result in a change in behavior from past versions. When processed, the Byte Order Mark will no longer appear in the result output from the component. | PPP: Generic Components | Medium | PPP-53428 |
Analytics and Machine Learning
| Description | Areas Affected | Risk | Issue ID |
| A new component, "Download Hugging Face Model", downloads models from Hugging Face for use with the "LLM - Text Generation (Base)" and "LLM - Text Generation (Chat)" components. Models downloaded using the "Download Hugging Face Model" component are stored in a <SharedPublicDir>/BIOVIAPipelinePilotLLMs folder. | PSM: Deep Learning | Low | PSM-2529 |
| A new component "LLM - Text Generation (Chat)" runs instruction-tuned (or chat) models from Hugging Face. | PSM: Deep Learning | Medium | PSM-2570 |
| A new component, "LLM - Text Generation (Base)", runs base models from Hugging Face. | PSM: Deep Learning | Medium | PSM-2612 |
| New example protocols are available to demonstrate the new Generative Data Processing collection. | PSM: Modeling | Low | PSM-2575 |
| A new utility component, "Downloads Dependencies for LLM", downloads Python packages used by the Generative Data Processing Collection. | PSM: Modeling | Low | PSM-2586 |
| A new component, "Learn R Gaussian Process Regression Model", creates a Gaussian Process Regression model. | PSM: R Statistics | Low | PSM-2005 |
| A new component, "One Pass of Bayesian Optimization", takes in labeled training samples and unlabeled candidate samples, builds a machine learning model from the labeled samples, and then outputs optimal candidate samples. | PSM: R Statistics | Low | PSM-2505 |
| A Concrete Compressive Strength dataset is added to the generic data included in Pipeline Pilot, and an example called "Build models of Concrete Formulation Strength" is available. | PSM: R Statistics | Low | PSM-2598 |
Biology Collections
| Description | Areas Affected | Risk | Issue ID |
|---|---|---|---|
| ChemSpider now requires a token to use the service. A sticky note was added to the Search PubChem for CAS Number example protocol indicating that the token needs to be set on the Find Molecule from InChi Key component to run the example. | PBIO: Example Protocols | Low | PBIO-6826 |
| UCSC Kent Utilities (faToTwoBit, wigToBigWig, and bigWigToWig) are upgraded to version 484. | PBIO: Analysis | Low | PBIO-6848 |
| Upgraded fastq-dump and prefetch to version 3.2.1. | PBIO: Analysis | Low | PBIO-6850 |
| Unused libraries are removed. | PBIO: Analysis | Low | PBIO-6857 |
| Failures from online BLAST searches due to issues on the NCBI server, such as CPU limit being exceeded, now generate a more meaningful error message. | PBIO: Online Components | Low | PBIO-6901 |
| The MIRA3 Assembler component and related example protocols are removed. It is recommended that you use the Velvet Assembler instead. | PBIO: Analysis | Low | PBIO-6911 |
| Unused libraries are removed. | PBIO: Analysis | Low | PBIO-6858 |
| Align Sequences to HMM (HMMER2 hmmalign), Build HMM From Alignment (HMMER2 hmmbuild), Search HMM File with Sequence (HMMER2 hmmpfam), and Search Sequence File with HMM (HMMER2 hmmsearch) components are removed. It is recommended that you rebuild HMMs and use the HMMER3 components instead. | PBIO: Analysis | Low | PBIO-6910 |
| Microsoft is removing support for VB Script (see https://techcommunity.microsoft.com/blog/windows-itpro-blog/vbscript-deprecation-timelines-and-next-steps/4148301). The FASTA Entry Prompt, Emboss Version, Alignment Viewer (JalView 2), Alignment Viewer (JalView), Heat Map Viewer (Java Treeview), and Mapping Alignment Viewer (Tablet) components are modified to no longer use VB Script. | PBIO: Analysis | Medium | PBIO-6847 |
| Bowtie 2 is upgraded to version 2.5.4. | PBIO: Analysis | Medium | PBIO-6851 |
| FASTQC was upgraded to version 0.12.1. | PBIO: Analysis | Medium | PBIO-6853 |
| Picard is upgraded to version 3.4.0. | PBIO: Analysis | Medium | PBIO-6854 |
| The biology collections are updated to work with Pipeline Pilot infrastructure changes. | PBIO: Analysis | Medium | PBIO-6855 |
| Tablet is upgraded to version 1.21.02.08. | PBIO: Analysis | Medium | PBIO-6856 |
| The biology collections are updated to work with Pipeline Pilot infrastructure changes. | PBIO: Analysis | Medium | PBIO-6870 |
| The biology collections are updated to work with Pipeline Pilot infrastructure changes. | PBIO: Analysis | Medium | PBIO-6907 |
| The biology collections are updated to work with Pipeline Pilot infrastructure changes. | PBIO: Analysis | Medium | PBIO-6908 |
| The biology collections are updated to work with Pipeline Pilot infrastructure changes. | PBIO: Analysis | Medium | PBIO-6909 |
| Updated biology collections to work with Python 3.12. | PBIO: Analysis | Medium | PBIO-6916 |
| The biology collections are updated to work with Pipeline Pilot infrastructure changes. | PBIO: Infrastructure | Medium | PBIO-6871 |
Chemistry Collection and SDK
Documents and Text Collection
| Description | Areas Affected | Risk | Issue ID |
| New components for searching the web and performing spell checking are provided through an integration with the Brave Search Engine. Registration for an API key is required, and Brave has both free and paid options. New components are: Search the Web (Brave Engine); Search the Web (Brave Engine) for Each Data; and Correct Word Spelling (Brave Engine).Microsoft no longer supports the Bing Search API, so the corresponding components are obsoleted: Search Bing; Search Bing for Each Data; and Correct Word Spelling (Bing). | TXT: Search Online | Low | TXT-1134 |
| A variety of cloud-based Large Language Model (LLM) Chatbots are now integrated in Pipeline Pilot with a new component, "Answers from LLM Chatbot (Openrouter)". Free and paid models from many cloud vendors, including OpenAI and Google, are supported via the Openrouter.ai API. Registration for an API Key is required. The following example protocols are available: * Demos/LLM Retrieval-Augmented Generation (RAG) * Tutorials/06 Analysis and Annotations/11 Question Answering with LLM Chatbots * Tutorials/06 Analysis and Annotations/12 AI Document Summaries via LLM Chatbot | TXT: Demos, TXT: Tutorials, TXT: Natural Language Processing | Low | TXT-1139 |
Materials Studio Collection
| Description | Areas Affected | Risk | Issue ID |
|---|---|---|---|
| You can now use the "Calculate Core Level Spectra" protocol to obtain the absolute position of the core level edge, and you can include spin-orbit splitting of the core level in the calculation of the spectrum. | MSC: Application | Low | MSC-7131 |
| New protocol "Calculate Hubbard U Values" refines U values for DFT+U CASTEP calculations. | MSC: Application | Low | MSC-7203 |
Fixed Defects
This release of BIOVIA Pipeline Pilot includes the following fixed defects.
| Severity | Description | Areas Affected | Risk | Defect |
|---|---|---|---|---|
| Major | Added a new feature to the Excel Reader that looks for unexpected DTD Entity definitions. This extra check has a performance penalty, and can be disabled by setting the parameter Additional Options/XXE Check to False. | PPP: Integration, PPP: Security | Low | PPP-53922 |
| Minor | Servers configured to use SAML from a 3rd party IdP for authentication no longer cause infinite redirects when the user could successfully authenticate with the SAML IdP but did not have the required authorization to use Pipeline Pilot or Web Port. The server now responds with 403 Forbidden. | PPC: Security | Low | PPC-11586 |
| Minor | This release restores the ability of an administrator to define a SAML assertion attribute as an external claim in the Groups admin page. Since this is a less common use case, the extra panel with the SAML attribute table is only displayed in an open state if a claim of this type has been defined. Otherwise, the administrator can explicitly open the table to insert a new SAML-based claim. | PPC: Administration | Low | PPC-12019 |
| Minor | The Server Port Usage field in the Admin Portal Server Configuration page is updated to reflect that SSL Only is now the preferred default configuration. The options for the field are now "SSL Only", "HTTP Only", and "SSL and HTTP" | PPP: Administration | Low | PPP-53966 |
| Minor | For certain administration pages (e.g., Groups, Permissions), the icon on the button used to close the editor panel and cancel changes for some administration pages such as Groups and Permissions is updated to clarify the function. | PPP: Administration | Low | PPP-54024 |
| Minor | Drop-down lists of user names in the Administration Portal are no longer missing if any of the names include Unicode characters. | PPP: Administration | Low | PPP-53720 |
| Minor | Support is improved for Unicode characters used in the Administration configutiil command line. | PPP: Administration | Low | PPP-53750 |
| Minor | During installation on Windows, a warning is given if the installation root path is too long and the installation directories risks exceeding the default Windows folder path maximum. | PPD: Packaging | Low | PPD-3040 |
| Minor | The system checker now checks correctly for the libnsl2 package. | PPD: Packaging | Medium | PPD-3048 |
| Minor | During installation, the system checker now includes library validation for Rocky Linux. | PPD: Packaging | Medium | PPD-3055 |
| Minor | The legacy MongoDB components are no longer supported in Pipeline Pilot 2026. Existing protocols that use these components must be updated to remove them. Note that the components were removed in an earlier release because their functionality was restricted to unsupported 3.x versions of the MongoDB database. | PPD: Packaging | Low | PPD-3110 |
| Minor | The Professional Client no longer flags a memory access violation error when opening a reporting Link Options dialog from within a secondary dialog such as a Data Series dialog. | PPP: Professional Client | Low | PPP-48949 |
| Minor | Edits to protocol or component version comments in the Show Versions dialog are now persisted when the expanded comment editor dialog is used and "Apply" is clicked before closing the dialog. | PPP: Professional Client | Low | PPP-53388 |
| Minor | The watch windows no longer display two separate vertical scrollbars in some cases. | PPP: Professional Client | Low | PPP-53838 |
| Minor | In Pipeline Pilot 2026, the functionality to render dashboards as PDF files and to support the Image Report Writer component is now switched to use a headless chrome browser. On Linux, this requires the use of a graphics library in the mesa-libgbm RPM. If you see a message about the missing gbm library, this RPM will need to be installed to the Linux machine where Pipeline Pilot is installed. | PPP: Reporting | Medium | PPP-53413 |
| Minor | The appearance of Highcharts radar chart axes is improved with dynamically determined data value ranges. | PPP: Reporting | Low | PPP-48953 |
| Minor | Javascript defined in "HTML Attributes" for item events in Highcharts charts is now executed in response to those events. | PPP: Reporting | Low | PPP-49281 |
| Minor | The Y-axis range determination is improved when outliers of a box plot series are not shown in the chart. | PPP: Reporting | Low | PPP-53194 |
| Minor | Bar chart error bars now work as expected when error series data is not sorted in the same order as the main series data. | PPP: Reporting | Low | PPP-53203 |
| Minor | In the Python (on Server) component, assigning a Python list to a property using syntax like props['variableName'] = [1, 2, 3] now requires that all members of the Python list have the same type and that type can be unambiguously converted to a basic Pipeline Pilot type, otherwise an error is thrown. Previously, lists with mixed types were automatically converted to Pipeline Pilot array values based only on the first value of the list, which could lead to unexpected values in the resulting Pipeline Pilot array value. For example, previously, props['variableName'] = [1, 'stringvalue'] would get converted to a Pipeline Pilot IntegerArray containing 1, 0. Now, the component will throw an error. Another example is that previously, props['variableName'] = [1, 2.5] would get converted to a Pipeline Pilot IntegerArray containing 1, 0. Now, this is converted to a Pipeline Pilot DoubleArrayValue containing 1, 2.5. | PPP: Component SDKs, PPP: Integration | Low | PPP-50650 |
| Minor | The getIthItem method of a HashTableValue in pilotpython.py, which is used in the Python (on Server) component, now works. | PPP: Component SDKs | Low | PPP-52797 |
| Minor | When using an external Python environment in the Python Script component, it is now possible to enclose the entire Python script in a try-except block without encountering an error. | PPP: Component SDKs | Low | PPP-53118 |
| Minor | The AVIF image format capability is removed from the Pillow module, which is deployed as a dependency of Matplotlib in the Python essentials. This action was taken because of a reported vulnerability in the removed library, which is not a pre-requisite of Matplotlib. | PPP: Component SDKs | Low | PPP-54035 |
| Minor | The issue where the Generate Empty Data component would fail with "Cannot dereference a NULL pointer" if the WhenToGenerate parameter was set to AfterEachProcess without any input data is fixed. | PPP: Generic Components | Low | PPP-53634 |
| Minor | The Pad Properties component no longer includes incorrect and unnecessary log messages in the form "WARN: Component XXXX is not registered" in scitegicerror_scisvr.log. | PPP: Generic Components | Low | PPP-52706 |
| Minor | A bullet point has been added to the help text of the Python Script and Python Jupyter Notebook components to warn users that the data types of incoming data may unexpectedly be "object" in the pandas DataFrame of input data, so some Python code may be necessary to set the data types of columns of the input data. | PPP: Documentation | Low | PPP-53955 |
Analytics and Machine Learning
| Severity | Description | Areas Affected | Risk | Defect |
| Minor | The Learn XG Boost Model component now works with versions of R 4.x that previously caused errors. | PSM: R Statistics | Low | PSM-2563 |
| Minor | An issue with the implementation for calculating singular value decomposition to invert a matrix, which is used when calculating Mahalanobis distance and in the Least Squares Curve Fit component, is fixed. | PSM: Not Categorized | Low | PSM-2600 |
Biology Collections
| Severity | Description | Areas Affected | Risk | Defect |
| Trivial | netCDF is added to the third-party tool list. | PBIO: Documentation | Low | PBIO-6774 |
Chemistry Collection and SDK
| severity | Description | Areas Affected | Risk | Defect |
|---|---|---|---|---|
| Critical | Fixed an issue where data folder is missing in Pipeline Pilot Chemistry Python SDK wheel packages and setting of IsotopeDataFilePath is not working in Python SDK. | PCHE: Other | Low | PCHE-10203 |
| Major | Fixed the issue of matching AND and OR isomers when setting flexmatch using full settings string instead of 'match=all'. Flexmatch string settings bug will be addressed in PCHE-10082. | PCHE: PPChemAPI, PCHE: Query Mapping | Low | PCHE-10060 |
| Major | Setting flexmatch switches behavior is not changed, and setting them resets the mapper. Instead, the behavior is properly documented in the help for API of ExactMap.setFlexMatchString: "Set the FLEXMATCH switches to use for matching." was changed to "Set the FLEXMATCH switches to use for matching. As a side effect, resets the mapper." The decision to keep the old behavior unchanged was due to the fact that a lot of developer-oriented code, as well as tests, relied heavily on the old behavior of setFlexMatchString | PCHE: Chemical Perception | Low | PCHE-10082 |
| Major | now, absolute enhanced stereo isomers of allenes are correctly matched between each other. | PCHE: Chemical Perception | Low | PCHE-10084 |
| Major | The tabs displayed within the Web Port Parameters tab now appear and behave correctly. In addition, the Chemistry Sketcher now works correctly. | PCHE: Sketchers | Low | PCHE-9754 |
| Minor | The following are fixed: The mapping and matching methods of
The backend function of ExactMap (the same as in PP Client) producing erroneous results for matching of isomers with Absolute configuration of allene group and enhanced stereo of sp3 center Note: Defining flexmatch after adding query resets the mapper and fails to produce matching was documented as a feature. | PCHE: Chemical Perception | Low | PCHE-10062 |
| Minor | When reading molecule from V3000 format, before stereo labels are assigned there is a chance to trigger a branch of code that triggers perception of the molecule. Because stereo labels were not set yet, this could lead to incorrect perception of the molecule, where a bond was interpreted as atropoisomer bond when in fact it was not. | PCHE: Chemical Perception | Low | PCHE-10095 |
| Minor | Updated the FindAtropisomers() function to optionally ignore stereo flags (via the considerStereoFlag parameter) and use internal rules for identifying atropisomer centers. | PCHE: PPChemAPI | Low | PCHE-10098 |
| Minor | Updated the FindAlleneCenters() function to include a check for the number of atoms to determine whether an allene is stereogenic. | PCHE: Chemical Perception | Low | PCHE-10115 |
| Minor | Updated the FindAlleneCenters() function to accept an axialStereoSymmetryViolationCheck parameter for optional symmetry violation checks, preserving original behavior by default. Also, introduced the m_skipAlleneDuringPerceive flag to avoid redundant FindAlleneCenters() calls. | PCHE: PPChemAPI | Low | PCHE-10151 |
| Minor | Resolved issue editing chemistry in monomers in reactions in monomer view. | PCHE: Pipette | Low | PCHE-10167 |
| Minor | Ensure + sign is added in reactions when adding reactants by default. A specific URL flag was causing this not to happen. | PCHE: Pipette | Low | PCHE-10169 |
| Minor | RegisterCheck of Pipeline Pilot Chemistry SDK no longer causes access violation exception for a particular reaction. | PCHE: PPChemAPI | Low | PCHE-10191 |
| Minor | Now, hydrogen bond in target won't be matched to any query bond tests that can be specified using SMARTS patterns. | PCHE: Query Mapping | Low | PCHE-10197 |
| Minor | dAA monomers now correctly appear in monomer searches. | PCHE: Pipette | Low | PCHE-10241 |
| Minor | Fixed an issue of reading CDXML files in Pipeline Pilot CDXML file reader. | PCHE: PPChemAPI | Low | PCHE-8560 |
| Minor | Reagent name and comment can be read and depicted with round brackets ( ) . | PCHE: File Formats | Low | PCHE-9512 |
| Minor | Added Chemdrawsupportedversions parameter in the Pipeline Pilot administrator page. | PCHE: Sketchers | Low | PCHE-9949 |
Materials Studio Collection
| Severity | Description | Areas Affected | Risk | Defect |
|---|---|---|---|---|
| Major | The protocol "Calculate Yield Stress and Critical Distortional Strain" now requires Zero Strain NVT Steps, Zero Strain NPT Steps, Equilibration Steps, and Production Steps to be between 1 and 2E9. | MSC: Examples | Low | MSC-7151 |
| Major | The "Create Polymer Network" and "Create Meso Polymer Network" protocols now support input of collection documents to specify mixtures of base resins, curing agents, or solvents. | MSC: Examples | Low | MSC-7231 |
| Major | Repeated runs of protocols using MACE forcefields could sometimes fail. This problem is now fixed. | MSC: Other | Low | MSC-7234 |
| Minor | Quantum Chemistry protocols in MSC can run on Windows servers | MSC: Other | Low | MSC-6664 |
| Minor | The Forcite tasks Energy Calculation, Cohesive Energy Density, and Elastic Constants components now have Use GPU in their Advanced options? | MSC: Application | Low | MSC-7076 |
| Minor | The issue of calculating the length of the molecule for in membrane sections in Build Mesoscale Membrane protocol is corrected. Now, Build Mesoscale Membrane protocol can calculate the membrane molecules' lengths from the maximum bead distance of molecules and if head and tail bead tags are present, uses the largest distance between head and tail beads. | MSC: Other | Low | MSC-7109 |
| Minor | Turbomole protocols in MSC Quantum Chemistry now execute correctly even if Python is not installed on the computer. | MSC: Application | Low | MSC-7129 |
| Minor | The number of parallel threads is now set correctly for Molecular Dynamics step of Update Loop at Run Monte Carlo Reactive Molecular Dynamics protocol. | MSC: Other | Low | MSC-7161 |
| Minor | Updated documentation for the Quantum Mechanics protocols in the Materials Studio Collection User Guide. | MSC: Documentation | Low | MSC-7213 |
| Minor | The Substitute Alloy Elements protocol now correctly substitutes elements in the structures in a study table. | MSC: Application | Low | MSC-7276 |
| Trivial | In the "Create Meso Polymer Network" protocol, you can now define reactions in terms of the bead type name without having to set the bead names in the input structures explicitly. | MSC: Examples | Low | MSC-7110 |
| Trivial | Calculate Thermal Conductivity protocol now supports Group Based summation method for electrostatic and van der Waals calculations on GPU. | MSC: Other | Low | MSC-7111 |
| Trivial | The example protocol "Pack O2 and N2 into Zeolites" now correctly sets the Mole Ratio for the mixture. | MSC: Examples | Low | MSC-7157 |
| Trivial | The Molecular Dynamics (LAMMPS) component now sets up calculations in the NVE ensemble as expected by recent version of LAMMPS. | MSC: Examples | Low | MSC-7172 |
| Trivial | The "Run Monte Carlo Reactive Molecular Dynamics" protocol now supports group based summation methods with a GPU | MSC: Other | Low | MSC-7245 |
| Trivial | To avoid diverging dynamics, the initial geometry optimization in the protocol "Mass and Charge Transport" is now carried out using Forcite instead of Amorphous Cell, in two parts: 1500 steps with motion groups fixed, and another 500 steps optimizing all degrees of freedom. | MSC: Examples | Low | MSC-7273 |
Notebook Collection
| Severity | Description | Areas Affected | Risk | Defect |
| Trivial | The Get Items from Lookup component now returns all properties of the Lookup items. | ANC: API | Low | ANC-298 |
| Trivial | The Data from Excel Section component now correctly ignores other section types than Excel sections. | ANC: API | Low | ANC-299 |
Resolution
BIOVIA Pipeline Pilot 2026 was released in November 2025 and is available for download at https://software.3ds.com under BIOVIA products:
Product line: Lab, Scientific and Content Solutions
Release: BIOVIA 2026
Level: BIOVIA 2026 Golden
Fixes for this level: N/A
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