Be the next big change > Dassault Systèmes

Be the Next Game Changer

INTERNSHIP - BIOVIA Biologics & Drug Design (Post-Doc)

United States, CA, San Diego

Imagine New Horizons

The Biologics and Drug Design team within Dassault Systèmes BIOVIA develops and validates scientific modeling and design methods for our life sciences customers. As a post-doc on the team, you will have access to our advanced modeling and machine learning algorithms and state of the art visualization, and use the BIOVIA Discovery Studio suite with Pipeline Pilot for the development of novel features and research applications.

This is a paid internship available with a flexible fall start date and duration.  This role is based in the Dassault Systèmes BIOVIA office at Dassault Systemes, BIOVIA Corp.  5005 Wateridge Vista Drive, San Diego, CA 92121

Do you have dreams? Do you enjoy a challenge? Here at Dassault Systèmes, we empower people with passion to change the world. 

Shape your career with 3DS! #WeAre3DS

What your role will be?
As part of your role, you will develop new methods to tackle protein design and drug discovery challenges such as robust de novo protein design or blind molecular docking.

This work will expose you to the widely adopted scientific development platform, Pipeline Pilot, and innovative research topics in biologics and drug design.

As part of the development process you will work with the Quality Assurance team to ensure automated test coverage of new functionality. Additionally, you will participate in discussions with Product Management and customer-facing teams on product direction and new features.

A peer-reviewed publication is desirable based on the outcome of the research.

The Challenges ahead

Areas of interest for potential projects include but are not limited to the following:

  • Protein modeling and design pipelines using machine learning models such as AlphaFold2, OpenFold, ProteinMPNN, etc.
  • Free energy methods for protein design and small molecule drug discovery applications
  • Binding kinetics and enhanced sampling

Your Key Success Factors

  • Ph.D. in computational chemistry, structural biology, or a related field
  • Working experience with one or more of the following:
    • In silico protein modeling and design
    • Free energy calculations
    • Machine learning algorithms applied to biological problems e.g. graph neural networks, transformers, transfer learning, etc.
  • Previous software development experience
  • Proficient in a programming language such as Python, C++, or Java
  • Experience with machine learning frameworks such as pytorch, keras, or tensorflow is desirable
  • Working experience in BIOVIA Pipeline Pilot is beneficial
  • Ability to work in a collaborative team
  • Attention to detail and scientific curiosity

Compensation for the role will be commensurate with experience. The expected hourly rate range will be between $19 per hour and $40 per hour.

Equal opportunity

In order to provide equal employment and advancement opportunities to all individuals, employment decisions at 3DS are based on merit, qualifications and abilities. 3DS is committed to a policy of non-discrimination and equal opportunity for all employees and qualified applicants without regard to race, color, religion, gender, sex (including pregnancy, childbirth or medical or common conditions related to pregnancy or childbirth), sexual orientation, gender identity, gender expression, marital status, familial status, national origin, ancestry, age (40 and above), disability, veteran status, military service, application for military service, genetic information, receipt of free medical care, or any other characteristic protected under applicable law. 3DS will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Covid statement

Our Company requires all U.S. employees to be fully vaccinated against COVID-19 and to provide documentation of full vaccination, unless qualified for a medical, religious or state-required accommodation or otherwise exempt consistent with applicable law.  Although accommodation requests will be considered (and granted where appropriate/possible), it may be determined that a candidate is unable to adequately perform the essential functions of the position without imposing an undue hardship due to customer requirements, staffing needs, or other business reasons. Definition of full-vaccination: Employees are considered to be fully vaccinated two weeks after their second dose in a 2-dose series or two weeks after a single-dose vaccine.
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