Be the Next Game Changer

INTERNSHIP - BIOVIA Biologics Drug Design (Post Doc)

United States, CA, San Diego

Internship

12/15/2022

529634

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Imagine New Horizons…

Be at the forefront of innovation! Serving customers of all sizes, in all industries from high-tech, life sciences, construction and transportation, we help businesses and people around the world create products and services in a novel, sustainable way.

Do you have dreams? Do you enjoy a challenge? Here at Dassault Systèmes, we empower people with passion to change the world.

As an intern within the Biologics Development Team within Dassault Systemes BIOVIA, you will help develop and validate scientific protein modeling and design methods for our life sciences customers.

Shape your career with 3DS! #WeAre3DS

This is a paid internship available with a flexible fall start date and duration. You will be working in the Dassault Systèmes BIOVIA office at 5005 Wateridge Vista Drive, San Diego, CA 92121.

What your role will be?

You will have access to our advanced modeling and machine learning algorithms and state of the art visualization, and use the BIOVIA Discovery Studio suite with Pipeline Pilot for the research.

As a Biologics Development Group post-doc, you will develop models to study protein design problems, such as antibody-antigen binding interfaces.

This work will expose you to the widely adopted scientific development platform, Pipeline Pilot, and the innovative research topics in biologics therapeutic design.

A peer-reviewed publication is desirable based on the outcome of the research.

The Challenges ahead

Develop a new algorithm for protein modeling and design. Area of interests include, but are not limited to the following:

Scoring function and ML model to rank protein – protein docking poses
None-linear B-cell Epitope mapping
Antibody paratope mapping and clustering
Protein post-translational modification

Your Key Success Factors

Postdoctoral researcher or associate
Working experience with in silico antibody design
Working experience with protein-protein docking algorithms and scoring functions
Experience in object oriented programing using either C++, Java, or Python
Working experience in BIOVIA Pipeline Pilot is desirable
Experience in developing protein 3D and 3D-shape descriptors is desirable
Experience in applying machine learning algorithms to solve biological problems is desirable
Ability to work in a collaborative team, attention to detail, scientific curiosity, strong communication skills, and a desire to develop high quality software.

*Compensation for the role will be commensurate with experience. The total expected compensation range will be between 43,000 and 83,000, representing the base salary (or annualized salary based on estimated hourly compensation) and target bonus

Equal opportunity

In order to provide equal employment and advancement opportunities to all individuals, employment decisions at 3DS are based on merit, qualifications and abilities. 3DS is committed to a policy of non-discrimination and equal opportunity for all employees and qualified applicants without regard to race, color, religion, gender, sex (including pregnancy, childbirth or medical or common conditions related to pregnancy or childbirth), sexual orientation, gender identity, gender expression, marital status, familial status, national origin, ancestry, age (40 and above), disability, veteran status, military service, application for military service, genetic information, receipt of free medical care, or any other characteristic protected under applicable law. 3DS will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Covid statement

Our Company requires all U.S. employees to be fully vaccinated against COVID-19 and to provide documentation of full vaccination, unless qualified for a medical, religious or state-required accommodation or otherwise exempt consistent with applicable law. Although accommodation requests will be considered (and granted where appropriate/possible), it may be determined that a candidate is unable to adequately perform the essential functions of the position without imposing an undue hardship due to customer requirements, staffing needs, or other business reasons. Definition of full-vaccination: Employees are considered to be fully vaccinated two weeks after their second dose in a 2-dose series or two weeks after a single-dose vaccine.

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